Dangerous Drugs - PPA
Phenylpropanolamine, or PPA, is a chemical that was used as the active ingredient in a variety of over-the-counter and prescription diet drugs, nasal decongestants, and cough medications including: Dexatrim, Acutrim, Robitussin, Comtrex, Triaminic and Tavist D. In 1990, U.S. consumers purchased over 6 billion doses of medications containing PPA.
In November 2000, U.S. regulators moved to take PPA off the consumer market due to the serious side effects presented by the drug. The Food and Drug Administration formally asked all drug companies to voluntarily cease marketing all products containing PPA. While research pointed to a higher risk for hemorrhagic strokes, or bleeding of the brain, in women, the FDA cautioned that men were also at risk. The strokes occurred within three days after people used the products.
Since 2003, the FDA has been helping companies reformulate their products away from use of the dangerous drug. Many companies voluntarily did so immediately after learning of PPA's risks, and for those that are less compliant, the FDA has discussed legal mandates to require them to switch over.
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